دانلود کتاب نقش فناوری نانو در سرطان ریه جامع

This book, The Role of Nanotechnology in Holistic Lung Cancer, is a comprehensive exploration of cutting-edge strategies in combating lung cancer, a disease that poses significant challenges worldwide. With 11 insightful chapters, this volume covers a wide array of topics ranging from the molecular mechanisms underlying lung cancer to the latest advancements in nanotechnology-based therapies. Each chapter offers valuable insights into different aspects of lung cancer management, including the roles of dendrimers, polymeric micelles, nanoemulsions, inhalation delivery systems, novel nano-imaging platforms, hydrogels, quantum dots, and nanotherapeutics. Additionally, it delves into ongoing research and clinical trials, shedding light on promising nanotechnological approaches for more effective lung cancer treatment. This book addresses the impact of carcinogenic pollutants on lung cancer development, highlighting the importance of understanding environmental factors and implementing intervention strategies. Chapter 1 explores the anatomy of the lung and the pathology of lung cancer. It then delves into nanotechnology’s role in targeted drug delivery for lung cancer, covering various nanoparticles such as magnetic nanoparticles (MNPs), polymeric nanoparticles, metal nanoparticles (MeNPs), dendrimers, and liposomes. These nanostructures offer innovative approaches for enhancing drug delivery precision in lung cancer treatment. Chapter 2 discusses dendrimers and linear polymers, outlining their characteristic features. It explores the etiology of lung cancer, encompassing factors like cigarette smoking, gender, race, genetics, obesity, infectious diseases, and environmental exposures. The pathogenesis section covers irregularities in signaling pathways, focusing on EGFR, TITF1, MYC family, tumor suppressor genes, and apoptosis evasion. The role of dendrimers in lung cancer therapy, both therapeutically and diagnostically, is succinctly presented with relevant tables. Chapter 3 explores polymeric micelles for lung cancer drug delivery, detailing their formation mechanism and assessing preclinical appli-cations. Specific polymers like SMA, PEG-b-PLA, PEG-b-PLGA, PEG-PCL, Pluronics, TPGS, and PEG-PAA are discussed. The chapter highlights polymeric micelles in clinical trials for lung cancer treatment, along with acknowledging the limitations associated with nano delivery using polymeric micelles. Chapter 4 explores nanotechnology’s role in overcoming physiological barriers in lung cancer therapy. Focusing on nanoemulsions in translational research, it details their composition, preparative methodology, and potential as a delivery tool in cancer therapy. The chapter delves into the mechanisms enhancing bioavailability and tumor availability of chemotherapeutics through nanoemulsions. Chapter 5 examines inhaled drug delivery systems, including pressurized metered dose inhalers, dry powder inhalers, and nebulizers. It focuses on recent advancements in inhalational nano-formulations for lung cancer, encompassing lipidic nano-carriers, dendrimers, and inorganic nanocarriers. The chapter addresses challenges in preparing inhalation nanochemotherapy, featuring a table of various nano-formulations with anticancer potential against lung cancer. Chapter 6 explores lung cancer detection methods, including conventional approaches, tissue imaging biopsy, and cancer biomarkers. It delves into nano-imaging systems, discussing metal/nonmetal nanoparticles like gold, iron oxide, carbon, manganese oxide, and cerium oxide. Polymericbased nanoparticles, such as gelatin, chitosan, and albumin, are examined as nano-imaging platforms. The chapter also highlights biologic nanocarriers and outlines current challenges in nano-imaging techniques. Chapter 7 explores hydrogels in lung cancer therapy, covering design, formulation, and methods of preparation. It delves into targeted drug delivery principles, both passive and active, in lung cancer using hydrogels. The chapter discusses ligand-functionalized hydrogels, their advantages, challenges, and role in lung cancer immunotherapy and gene therapy. Various types of hydrogels and their toxicity/pharmacokinetic profiling are outlined, concluding with future perspectives. Chapter 8 provides quantum dots ant its role against lung cancer. The chapter addresses issues in nonsmall cell lung cancer (NSCLC), emphasizing the need for innovative approaches, particularly focusing on carbon quantum dots (CQDs) and their applications in healthcare bioimaging, diagnosis, targeting cancer cells, and drug delivery. The comprehensive Chapter 9 explores the pivotal role of nanotechnology in lung cancer treatment, delving into innovative approaches, enhanced drug efficacy with nanoparticles, and the transformative impact of inhalational nanotherapy. Current research areas encompass liganddecorated nanoparticles, biotargeting ligands, nanosized drug carriers like carbon nanotubes and magnetic nanoparticles. The chapter also covers sustainable practices using natural sources for nanoparticle synthesis, novel approaches with tellurium nanostars, and the intersection of immunotherapy with molecular pathways for targeted lung cancer treatment. Chapter 10 explores nanotherapeutic approaches for lung cancer, focusing on nanostructured lipid carriers, liposomes, polymeric nanoparticles, and magnetic nanoparticles. It provides insights into advanced drug-delivery systems. The conclusion emphasizes the significance of these nanotechnologies in lung cancer treatment and offers future perspectives for continued advancements in this field. Chapter 11 explores diverse polymeric nanoparticles (PLGA, chitosan, dendrimers, polyethylene imine, PHEA, PEG, and polyspermine) for lung carcinoma therapeutics. It delves into clearance strategies, toxicity factors, and size, biodegradability, shape, charge, disease state, and interactions affecting inhaled nanoparticles. Receptor-mediated gene delivery to lung cancer is examined through FRA, RGD peptide, EGFR, CD44, and transferrin receptor. The chapter concludes by addressing challenges in polymeric nanoparticle-based drug/gene delivery for lung cancer. Chapter 12 covers solid lipid nanoparticles (SLNs) for lung cancer treatment, exploring their composition and various preparation methods like high-pressure homogenization and solvent evaporation. It delves into SLNbased gene delivery, inhalable drug delivery, and the mechanisms of SLN action in lung cancer, including passive and active delivery, co-delivery, antiadhesion, and the pulmonary route. The text provides a concise overview of the current status of nanoparticles in lung cancer therapy. Chapter 13 delves into liposome structure, composition, classification, preparation methods, and drug delivery systems. It explores pH-sensitive and long-circulating liposomes, detailing drug targeting strategies like passive and active targeting, including receptor-based targeting. Challenges in lung cancer therapy, liposome stability, and various stimuliactivated liposomes for lung cancer treatment are discussed. The chapter also covers polymer-functionalized liposomes, clinical trial formulations, and challenges for future prospects. In our endeavor to eliminate printing errors, despite meticulous efforts, inadvertent mistakes may have occurred. We humbly request notification of any identified errors and genuinely appreciate constructive suggestions, comments, and criticism on the book’s subject matter. This feedback is invaluable for enhancing future editions. Heartfelt gratitude is extended to the contributing authors whose chapters were instrumental in completing this book. Our indebtedness extends to all who supported its completion, acknowledging the indispensable role of Apple Academic Press (CRC Press). Special thanks to Mrs. Sheetal Kumar, Assistant Publishing Manager, for her scientific knowledge, helpful demeanor, and encouragement. Further, we extend our gratitude to Prof. M. P. Pandey, Vice Chancellor, and Prof. Navneet Verma of IFTM University, Moradabad, India, for their generous support. Lastly, profound thanks are extended to our parents, as their unwavering encouragement has played a pivotal role in bringing this book to fruition.