Ovarian cancer is the general termfor a variety of malignancies that arise in the fallopian tube and ovary. While subtypes of ovarian cancer differ in frequency and prognosis, high-grade serous is the most common and remains one of the deadliest cancers. This poor outcome results from three major limitations: (1) late-stage diagnosis due to nonspecific symptoms and no definitive screening tests, (2) high rate of recurrence and development of chemoresistant disease, and (3) substantial heterogeneity that has hindered the identification of new therapies.
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