دانلود کتاب اپیدمیولوژی اپی ژنتیک

This book joins two fields, epidemiology and epigenetics, to take advantage of their respective strengths in creating the science of epigenetic epidemiology. Epidemiology is the study of the frequency, distribution, and determinants of health and disease in humans. As a science fundamental to the study of public health, epidemiology is concerned with the prevention and effective control of disease. Epidemiology has early roots with the Greek physician Hippocrates, was and is essential in resolving infectious disease epidemics and pandemics ranging from cholera to COVID-19, and takes center stage in unveiling the causes of the chronic disease epidemics of our times including cardiovascular disease, diabetes, and cancer. Epigenetics is the mitotically heritable state of the gene expression potential. Gene expression is the response to cell-specific extracellular signals, and epigenetic mechanisms such as DNA methylation and histone modification govern the ability to respond appropriately to these signals. While the field of epigenetics has evolved over the past four decades, interest has been increasing exponentially. While initial work was conducted in plants and animal models, the focus has shifted on the role of epigenetics in human health and disease. Many intriguing and important observations have emerged, but numerous fundamental questions in epigenetic mechanisms in humans remain unanswered, providing abundant opportunities for discovery in the context of epidemiologic studies.