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In 2004, we were asked whether we would be willing to organize a book on inactivation mechanisms in calcium channels. This seemed overly focused, and we made a counterproposal to have a comprehensive book on calcium channels. It took almost 18 months to collect the more than 20 chapters, but the end result was a comprehensive book that covered the state of knowledge on calcium channels at the time. Much has happened globally since 2004. The world is ruled by social media, and Facebook, YouTube, Twitter, and Instagram are now part and parcel of our science communications, but they have also served as platforms for science denial and disinformation. The publishing world has been transformed through rapid online publications, but it has been inundated with a plethora of predatory journals that pollute the purity of scientific output. Through these changes, the calcium channel field has endured, but there have been a number of changes. Prior to the early 2000s, large scientific conferences, such as the Society for Neuroscience annual conference or the Biophysical Society meetings, had multiple oral sessions dedicated to calcium channels, and this is now no longer the case. As a way of bringing the calcium channel field together, we organized five international calcium channel conferences, always in a different location across the globe. This was subsequently complemented by the European calcium channel meeting organized by colleagues at the University of Innsbruck. These types of activities have fostered scientific exchange and helped build a sense of camaraderie, and many of the regulars at these conferences are participants in this book. It is interesting to note that a dozen of the authors of the current book also contributed to the earlier book, in some cases as trainees who are now firmly established leaders in the field, and there are many contributors who constitute a newer cadre of calcium channel experts. Sadly, we lost one of the true greats of calcium channel physiology due to the unfortunate passing of Dr. David Yue in 2014, but his legacy lives on through the outstanding work by his former trainees such as Drs. Dick and Ben Johny. There have been numerous advances in the calcium channel field over the past two decades. Due to rapid genetic sequencing, the field of calcium channelopathies has expanded dramatically, and has given rise to parent-led organizations such as the CACNA1A foundation. The availability of new technical approaches such as CRISPR has helped provide deeper insights into the physiological and pathophysiological roles of calcium channels. Perhaps, most impressively, the availability of crystal and cryo-EM structural informa tion as highlighted by Dr. Catterall has dramatically advanced the field and will have a major impact on drug discovery for the treatment of calcium channel– related disorders. The 2022 edition of Voltage-Gated Calcium Channels builds on the large body of information contained in the earlier book, but greatly extends this content to incorporate these new and exciting developments. The first section covers the most important structural and molecular aspects of voltage-gated calcium channels and their associated ancillary subunits, but also the importance of splice variation and RNA editing which contribute to extend their diversity and physiological roles. The second section deals with the different aspects of their regulation, ranging from their genetic control to their trafficking and regulation at the plasma membrane, and also their association with other channels and receptors. The third section is dedicated to their implication in the development of human disorders, a field that has expanded dramatically over the last years and continues to be one of the fastest growing research areas. Finally, the fourth section naturally covers the different aspects of their pharmacology, ranging from molecular pharmacology to a variety of small molecules and peptides that not only represent invaluable tools for the physiological study of calcium channels but also represent potential pharmacological tools for therapeutic intervention. We would like to warmly thank all of the authors without whom this second edition would not have been possible. We believe that to have all of this information in a single volume provides a fantastic resource for both those actively involved in the field and for those wishing to find out more about particular aspects of calcium channels.