دانلود کتاب تعریف حجم هدف در پرتو انکولوژی

The history of radiation therapy for malignant diseases dates back throughout almost the complete twentieth century. Neither three-dimensional cross-sectional imaging, such as computed tomography or magnetic resonance imaging, nor functional imaging, such as positron-emission tomography (PET), was available during the first decades. This resulted in treatment plan­ning approaches that most of today’s radiation oncologists are completely unfamiliar with. One particular example highlighting the development in a highly radio-curable malignancy is Hodgkin’s lymphoma. Compared to his­torical extended-field radiotherapy based on bony landmarks defining the field borders, we have witnessed the introduction of involved field and involved node radiotherapy, as well as PET-guided or -adapted treatment selection algorithms. Our ability to account for organ motion during treat­ment delivery has changed the way of administering radiation to the lung and mediastinum. Simultaneously, evolution of image-guided and high-precision application technology has outperformed clinicians’ ability to precisely define the clinical target volume (CTV) in a number of diseases. Practicing radiation oncologists have to make several important decisions during treat­ment planning and realization, one patient at a time. It all starts with staging, multidisciplinary discussion, and volume delineation, in case radiotherapy is indicated and recommended. It would be of limited or no value to precisely deliver the prescribed treatment to an incorrectly defined CTV. Artificial intelligence and deep learning are starting to impact the diagnostic and treat­ment planning processes and are likely to modify several parts of the present workflow.

The purpose of this book is to provide practicing radiation oncologists and therapists, as well as those in training, with a concise overview of the most important and up-to-date information pertaining to target volume definition. Several chapters, e.g., those dealing with lymphoma, sarcoma, and spine/spi­nal cord malignancies, not only include common clinical scenarios but also present challenging cases and rare cancer types. The issue of interobserver variability is addressed, and when available, the reader is introduced to con­sensus guidelines. The latter have evolved significantly after publication of the first edition of this textbook in 2015. Therefore, a completely updated second edition had to be prepared.

We are most grateful for the enthusiasm and courtesy all chapter authors showed during preparation of this truly international volume and for the fruit­ful discussion with many colleagues. The SARS-CoV-2 pandemic has unfortunately delayed the preparation of this second edition. Eventually, all contributors managed to deliver their up-to-date chapters. We also appreciate the excellent long-term support from the publisher. We hope that the reader will find this book to be a useful summary of current knowledge. Only con­tinued cooperative research will provide a better basis for tolerable and effi­cacious treatment regimens, exploiting the promises put forward by the emerging concepts of personalized, ablative, and adaptive radiation therapy.