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Musculoskeletal disorders are the most common reason for hospitalizations and, after cardiovascular diseases, the second largest cost driver in healthcare. Every physician will encounter patients with orthopedic pathologies during their career. This necessitates a basic knowledge of musculoskeletal diseases, not least because overlooking these can lead to significant consequences. The challenge for the medical student, the general practitioner or even the specialist in orthopedic surgery is keeping the overview, as orthopedic surgery is a very broad field. This book is a summary of the basic knowledge, the so-called “must-knows” of orthopedic surgery. It serves to maintain an overview for those who are or will become physicians, and as a base for aspiring orthopedic surgeons. Therefore, the focus is on presenting a concise content. The chapters are written by renowned specialists from the Balgrist University Hospital, who are at the forefront of their specialized field. They are lecturers at the University of Zurich and experienced in teaching and didactics. Special thanks go to them. Thanks also go to Mr. Noah Gieriet, a medical student from Zurich, who brought in the perspective of a medical student and learner, under the supervision of PD Dr. S. Bouaicha. The informative illustrations are thanks to Mrs. Dalkowski, and the creation of the book would not have been so efficient without the constant support of Mrs. Scheddin and the Springer-Verlag. The first edition of this book is dedicated to Prof. em. Dr. Christian Gerber. He has dedicated his life to orthopedic surgery and has greatly contributed to its evolution. I wish you an inspiring read and that your curiosity will be ignited for this exciting field of medicine.