دانلود کتاب داروی سرطان هلند–فری

Our understanding of cancer at themolecular, cellular, and clinical levels continues to expand. Translation of molecular diagnostics and therapeutics to the clinic has begun to realize the promise of precision medicine with the development and approval of dozens of new targeted drugs, antibodies, and predictive biomarkers. Assimilating this knowledge poses an acute challenge for students, residents, fellows, established practitioners of oncology, and other health care providers. Laboratory-based investigators seeking to translate their discoveries to human application require an accurate overview of clinical oncology, informed by cancer biology. As new diagnostics, therapies, and preventive strategies may now be applicable across multiple disease sites, it is essential that pharmaceutical and biotechnology companies understand the new advances and the unmet needs across the entire field of oncology. This 10th Edition of Cancer Medicine provides a comprehensive synthesis of clinical oncology and the principles underlying approaches to prevention, early detection, diagnosis, and therapeutic management of cancer. Biological hallmarks of cancer and the clinical manifestations of neoplastic diseases are described. Pathways and processes that explain the origin and pathogenesis of neoplasms are presented. Transformational technologies are discussed in depth to improve the understanding of technical procedures such as deep sequencing, methods for measuring epigenetic modification of DNA and histones, transcriptional profiling, ncRNAs, specific functions of RNAs, proteomics, and metabolomics.The heterogeneity within and between cancers and their metastases is described, and the implications for clinical management are discussed. Quantitative oncology is explained in simple terms, providing an introduction to systems biology, biostatistics, bioinformatics, and novel trial design. This work includes concise guidelines for the use of both drugs that are approved by the Food andDrug Administrations and novel agents. As in the past editions, there is an emphasis on multidisciplinary patient care including surgical and radiation oncology, psycho-oncology, survivorship, and population science. This volume should be of value to oncologists of every discipline. The editors have chosen experts who have written authoritatively about the disciplines and diseases covered in their respective chapters. As the world of science and medicine chip away the unknowns of the cancer process and its prevention and therapy, we believe this work will provide a platform for the current status of oncology and will prepare the reader for a critical evaluation of discoveries still to come.