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Since the beginning of modern scientifically-based medicine, there has been a progression from generalists to specialists. Surgeons and internists divided up with surgical steel on one side and pharmaceuticals on the other. Then the internists Balkanized their field by organ system, with doctors identifying as cardiologists, pulmonologist, endocrinologists, and nephrologists among others. From there the specialization continued with subspecialists in hepatology, electrophysiology, and diabetology, expanding our vocabulary. For a long time, nephrology resisted the siren call of further specialization, but the last few decades have seen resistance crumble as nephrologists differentiated into transplant nephrologists, interventional nephrologists, and most importantly (given the book you are holding) critical care nephrologists. The intersection of the intensive care unit (ICU) and nephrology is decades old. Although the role of the nephrologist in the ICU has morphed over the past 50 years, it is clear ICU patients are getting more complex and the modern nephrologist needs to understand the impact of critical care on the kidney as well as be aware of any advances that benefit the critically ill. It is with this backdrop that we created the first edition of The Handbook of Critical Care Nephrology. The Handbook of Critical Care Nephrology covers a breadth of topics. Whereas some chapters cover bread-and-butter nephrology topics such as the prevention and care of acute kidney injury or the timing, dose, and modality of kidney replacement therapy in the ICU, this handbook offers much more. It covers a wealth of critical care topics including chapters on shock, acute respiratory distress syndrome (ARDS), and the care of transplant patients in the ICU. Beyond these, there are chapters dedicated to electrolytes and acid–base abnormalities in critically ill patients. We have attempted to create a handbook that reinforces the basic tenets of nephrology care in the ICU while expanding on aspects of critical care that nephrologists (and others) are less familiar with, including but not limited to extracorporeal membrane oxygenation (ECMO), intoxications, and left ventricular assist devices. We have compiled 56 chapters with the goal that each chapter can be read in a single sitting. The chapters have been written by international experts, many of whom have published research on their chapter topic. These chapters average less than 3,000 words and are chock-full of clinical pearls. In addition to easy-to-digest chapters, when possible we have constructed visual abstracts for two or three of the major studies/trials for that topic. We specifically targeted older papers that do not have preexisting visual abstracts. As an added bonus, the PDFs of these visual abstracts can be used in talks or to bludgeon the other side in your latest evidence-based Twitter feud. The Handbook of Critical Care Nephrology is a streamlined introduction to the complex care of patients in the ICU with kidney issues. This book is not meant to be exhaustive. It is geared toward medical students, interns, and residents who are interested in developing a broad knowledge base. In addition, we expect that internists, surgeons, anesthetists, advanced practice nurses, physician assistants, and pharmacists will find this book useful. Given the visual abstracts for many of the older classic studies and trials, nephrologists and intensivists may find them useful as teaching tools. Regardless, we hope you enjoy it.