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Digitalization is one of the most dramatic and impactful megatrends occurring across business, industry, and commerce. Digital technologies, systems, and platforms are affecting how we collaborate and exchange information across a supply chain, and how we integrate, manage, and control supply chain operations. Digitalization potentially enables a strong digital thread connecting an entire physical supply chain. The Digital Supply Chain examines and analyzes in depth the impact of digitalization on the design, management, and control of contemporary and future supply chains. In Chapter 1, MacCarthy and Ivanov provide an overview of the principal technologies and systems that offer the most promise in linking the virtual and physical worlds to improve supply chain performance. These include smart factories, smart warehouses, smart logistics, cloud-based systems, and digital platforms, as well as the computational engines powered by Analytics, Data Science and Artificial Intelligence. Emerging technologies likely to influence future supply chains are also discussed, including Blockchain, Digital Twins, Internet of Things, 5G, Edge, and Fog computing. The chapter describes an evolving spectrum from digitally immature to digitally enabled and digitally transformed supply chains. The transformative effects of the digitalization of supply chains will affect supply systems in diverse ways providing not only many new opportunities but also giving rise to many challenges in data rich supply chain ecosystems. The remaining chapters of the book develop, expand, and critically analyze all of the themes discussed in the introductory chapter. In the second part of the book, Chapters 2e8 describe, analyze, and critically appraise the building blocks and enabling technologies for the digital supply chain. In Chapter 3, Mourtzis, Angelopoulos, and Panopoulos chart the evolution of digital manufacturing from the early applications of computers in industry to today’s digitally rich Smart Manufacturing ecosystems. They highlight the key components, frameworks, and architectures of the Smart Factory, a cornerstone for Industry 4.0 (I4.0), and the interoperability challenges it presents. In Chapter 4, Winkelhaus and Grosse apply a sociotechnical lens to understand and analyze the combination of human and technology components needed in contemporary Smart Warehousing systems. In Chapter 5, Baziyad, Kayvanfar, and Kinra examine the emerging IoT paradigm and its supporting technologies that have the potential to facilitate smart manufacturing and enable future Digital Supply Chains. In Chapter 6, Zhang, MacCarthy and Ivanov review key computing advances that underpin and enable the Digital Supply Chain and have the potential to transform future supply chains, namely, the Cloud, Platforms, and Digital Twins. In Chapter 7, Brusset, La Torre and Broekaert introduce the computational approaches, algorithms, analytics, and AI that can be harnessed to underpin data-driven supply chain decision-making. In Chapter 7, Pettit, Wang, and Beresford trace the impact of digitalization on the logistics sector and discuss how digitally enabled logistics can improve supply chain transparency, operational efficiency, and responsiveness. In Chapter 8, Treiblmaier, Rejeb, and Ahmed review the drivers, inhibitors, and industrial applications of one of the most iconic digital technologies that is set to influence the management and control of future supply chainsdthe Blockchain. The third part of the book, Chapters 9e13, addresses opportunities and challenges in the management of the Digital Supply Chain. In Chapter 9, Spanaki, Karafili, and Despoudi analyze the significant challenges in ensuring data quality and achieving effective data governance in the shared data architectures that accompany the digitalization of the supply chain. In Chapter 10, Chan considers one of the most dominant supply chain management challengesdtraceabilitydand discusses how to design robust digital systems to ensure products can be traced and tracked across the supply chain. In Chapter 11, Cox examines the evolution of digital support for both routine and strategic activities in purchasing and procurement, one of the most critical supply chain management functions. In Chapter 12, Jha, Verma, and Bose use an information processing perspective to examine opportunities and approaches for measuring and managing performance in the Digital Supply Chain. In Chapter 13, Cha reviews the state of knowledge on Supply Chain Cyber Security from both practitioner and academic perspectives, providing guidance for detection and defense against the many potential vulnerabilities at the interface of the digital and physical worlds. Many chapters throughout the book provide detailed examples of practice. Part 4, encompassing Chapters 14e20, examines digitalization of the supply chain in six important business and industrial sectors.