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The origins of electrospinning technology dates back to the days when Jean- Antoine Nollett first electrosprayed water with an electric charge generated from a Leyden Jar, back in 1746. But it was not until 1902 that Cooley filed the first patent on electrospinning based on that process. It took yet another half a cen-tury before Geoffrey Taylor in 1969 modeled the deformation of a liquid droplet in an electric field as the Taylor’s cone. Electrospinning of nanofibers has come a long way since then, thanks to the intensive burst of research since the 1990s when academia got interested in the process. Today, it is a popular and versatile technology with several books published on electrospinning in recent years, including The Science and Technology of Polymer Nanofibers (Wiley 2008) by one of the present editors. Nanofiber science has made impressive advances and recently discovered a myriad of applications for this unique nanomaterial. Most of these developments occurred during the last two to three decades of research; the term “electrospinning” itself came into common use only as recently as 1995. Among the many different routes to fabricating nanofibers, electrospinning remains the most popular because of its simplicity, low- cost, and scalability. By definition, nanofibers are 1- D nanomaterials that have diameterd <100 nm. While there is scientific and regulatory agreement on this size range, many research publications as well as some regulatory organizations accommodate an upper limit of a d = 1000 nm. Electrospinning is able to fabricate nanofibers that fall within both size ranges.