دانلود کتاب اکسید دوتریوم و دوتراسیون در علوم زیستی

Water in tissues and cells intervenes with cellular components. The interactions of water affect the structures, dynamics, and functions of biomolecules, including pro­teins, nucleic acids, and lipids. Biomolecular folding, stability, and binding are mediated by water through hydrogen bonds and hydrophobic interaction. Water also participates in catalytic functions of enzymes, and plays crucial roles in protein secondary and tertiary structures, nucleic acid helix formation, and lipid bilayer membranes.

Deuterium is a naturally occurring, stable, and non-radioactive isotope of hydro­gen. There are distinct differences in physical properties between deuterium oxide (D2O) and regular water (H2O). Investigations of deuterium oxide and deuteration is a promising component in various areas of sciences, including physics, chemistry, biochemistry, biomedical, pharmacology, and biotechnology.

There are distinct differences between deuterium oxide (heavy water) and hydro­gen oxide (regular water) as the solvent for biological systems. Changes in the aque­ous H2O environment with D2O affect the interaction, stability, and functions of biomolecules, including the strengths of hydrogen bond, hydrophobic interaction, and carbon-hydrogen bond that serve as the driving forces for various biomolecular processes.

There are many advances that have been made in the past decades toward the understanding of functions, interactions, and implications of deuterium oxide and deuteration. Studies of deuterium oxide and deuteration effects on the interactions, stability, and functions of biomolecules offer valuable applications to health-related issues, including diseases, vaccines, and drugs. Deuterium oxide and deuteration also mediate pharmacokinetic process involving adsorption, distribution, metabo­lism, excretion, and toxicity.

An organized, concise overview of deuterium oxide and deuteration in biosci­ences is needed for readers who are exposed to this important subject, particularly for students and researchers in the areas of biochemistry, biophysics, biomedical sciences, and pharmacology, who are interested in gaining knowledge on the back­ground and implications of deuterium oxide and deuteration.