دانلود کتاب آسیب نوری DNA – از جذب نور تا پاسخ های سلولی و سرطان پوست

Induction of DNA damage by sunlight has been recognized for decades as a major deleterious event in living organisms. Consequently, in recent decades many studies have been devoted to elucidate the molecular processes triggered by absorption of ultraviolet (UV) light by nucleic acids, to understand the possible pathological consequences and the possible repair routes, allowing fundamental advances in our understanding of these processes. Many of the major findings gained before the first year of this millennium are gathered in a volume of the Comprehensive Series in Photochemical & Photobiological Sciences, a book entitled From DNA Lesions to Mutations, Skin Cancer and Cell Death, edited by E. Sage, R. Drouin and M. Rouabhia, published in 2005. However, in recent years the study of the photoactivated dynamics of DNA has been one of the hottest topics in photochemistry, and major breakthroughs have been made in photobiological research. Technical advances also occurred in all fields and provided novel information: ●● Theoretical approaches and time-resolved spectroscopy investigation of DNA model systems dramatically improved our understanding at the sub-picosecond timescale of the photochemical processes. ●● Photochemical experiments on model system of increasing complexity provided information on structural and sequence effects. ●● State-of- the- art biological tools opened new perspectives on the cellular response to photodamage, including repair, mutagenesis, trans-lesion synthesis and non-genetic effects. In addition, the advances made both from technical and scientific points of view made it possible for scientists with different expertise to understand each other, to create a common research ground that is fully multidisciplinary.