دانلود کتاب مبانی شیمی پورفیرین – رویکرد قرن بیست و یکم

Why porphyrins? They are in our blood – literally – and give it the red color (Greek πoρφÚρα, porphyra, “purple”). Porphyrin is the ligand that encapsulates iron in heme, the active site of the red blood cell protein hemoglobin. Without hemoproteins, life as we know it on this planet would not exist. With every breath we take, the iron in heme binds dioxygen (O2) at high partial pressure in our lungs via a delicately balanced cooperative binding process. The oxygenated hemoglobin in red blood cells embarks on a journey through our circulatory system before releasing oxygen from the iron at low partial pressure in the tissues. Humans have understood the importance of blood since the very beginning of their self-awareness, and the quest to understand its properties have been at the heart of the development of both medicine and science. The disciplines of chemistry and biochemistry have given us the tools to understand just how hemoglobinworks and the exquisite functions of the porphyrin ligand and iron in controlling the cooperative binding process.