Coeliac disease (CD) has customarily a benign outcome after gluten-free diet with symptoms that resolve within a few weeks while normal epithelial architecture is recovered within one to two years (see text by S Varma, S Krishnareddy). Yet, iterative follow-up of biopsies has revealed that histological recovery is delayed in some patients. Notably one population-based study led in 7648 celiac patients in Sweden showed persistent villous atrophy in 43% cases among individuals biopsied one to two years and two to five years after diagnosis.
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