دانلود کتاب دارورسانی به مغز – مفاهیم، روش ها و رویکردهای فیزیولوژیکی

More than four decades have passed since Reese, Karnovsky, and Brightman used electron microscopy to unequivocally establish that tight junctions between brain endothelial cells form the blood–brain barrier (Brightman and Reese 1969; Reese and Karnovsky 1967). This fi nding ushered in a new era of research and science investigating precisely what factors determine transport across the blood–brain barrier (BBB), as well as the blood–cerebrospinal fl uid barriers (BCSFB) formed by tight junctions between cells of the choroid plexus and arachnoid epithelia. Much interest developed around when and how these barriers to the central nervous system (CNS) form, as well as the interplay between components of the neurovascular unit (principally endothelial cells and their associated astrocytes, pericytes, immune cells, and neurons) that dynamically regulate the BBB. Along with this work, there has been a steady rise in the level of interest and research surrounding drug delivery to the brain. Indeed, there are now more than 10,000 citations in PubMed for articles retrieved using the search phrase “drug delivery” along with “brain” or “central nervous system”.