دانلود کتاب درسی دیابت – ویرایش ششم

It is nearly seven years since the last edition of the Textbook of Diabetes was published, during which time there have been many exciting developments in our understanding of diabetes and novel treatments that have improved the lives of those living with diabetes. Despite our ability to alleviate the risk of its long-term complications, the global burden of diabetes continues to rise as the prevalence inexorably increases. According to the International Diabetes Federation, diabetes now affects 537 million adults, compared with 415 million when the last edition was published. Over three-quarters of people with diabetes live in low-and middle-income countries and diabetes causes 6.7 million deaths a year, approximately one every five seconds. The cost of treating diabetes has reached almost US$1 trillion per annum, a threefold increase over the last 15 years. The need for accurate and up-to- date information to help healthcare professionals support people with diabetes has never been greater. Ironically, as the volume of information and diversity of digital resources have increased, many are finding it overwhelming to keep abreast of the new advances. It is particularly challenging to determine the validity of many source materials. In this textbook we aim to bring together a series of chapters from internationally leading diabetes experts who provide accurate and clinically relevant information to both academic and practising diabetes healthcare professionals. We have retained the structure from the previous edition, with a similar length and number of chapters. The centenary of the discovery of insulin has just passed and the book begins with a history of diabetes that provides many valuable insights from the past. We then move through the epidemiology of diabetes, the physiology of glucose metabolism, and the pathogenesis of diabetes, before sections on clinical management. A discussion of the microvascular and macrovascular complications then follows, after which there are sections on the psychosocial aspects of diabetes, the management of diabetes in special groups, and models of care, before a final section to glimpse into the future. New chapters include an overview of glucose homeostasis and the central control of glucose metabolism, as well as chapters on the genetics and management of obesity to recognize the close relationship between obesity and type 2 diabetes. There is a new chapter on the emerging topic of biomarkers and precision medicine, while the rapid advance in diabetes technology has necessitated a split into separate chapters on glucose monitoring and insulin delivery. Transplantation has moved from future treatments to current management to acknowledge its current place in clinical care. In the macrovascular section, we have added a new chapter on heart failure, which has come to the fore as a result of the sodium–glucose cotransporter 2 (SGLT-2) inhibitor cardiovascular outcome trials. Oral health and sleep are added to the list of other areas of diabetes complications, while the importance of social determinants of health and ethnicity, culture, and religion is now included in the psychosocial aspects of diabetes section. The final new chapter describes managing diabetes in low-to middle-income countries, where the majority of people with diabetes live. As editors, we are only too aware of the hard work that goes into the production of a comprehensive and up-to- date book such as this. For this edition the pressures of the Covid-19 pandemic added to the challenges of bringing the book to fruition. Our thanks go to each and every chapter author who, despite busy academic, clinical, and professional lives, was prepared to devote the time, energy, and expertise to provide their essential contributions to the text. Thank you for your forbearance of our nagging e-mails! We are also grateful for the support we have received from our publisher, Wiley-Blackwell. Our commissioning editor Jennifer Seward, who took over from Priyanka Gibbons during the book’s development, has provided guidance and encouragement. Our thanks also go to Rajalaxmi Rajendrasingh, Sally Osborn, and the rest of the Wiley-Blackwell team. The book looks even better than the last edition! We would like to pay tribute to Clive Cockram and Barry Goldstein, our editing colleagues for the fourth and fifth editions. You were missed this time round. We hope you enjoy reading the book, whether it be dipping in or reading from cover to cover, as much as we did editing it. We have taken away useful, novel information that will aid in our daily professional lives and hope that this book will help you to support the people with diabetes you know in the widest sense of this meaning.