دانلود کتاب چاقی، پیری و طول عمر

The global increase in life expectancy, along with the rising prevalence of the ageing population with obesity, represents an intertwined phenomenon and a pressing public health challenge. Obesity is a complex and heterogeneous condition that shares a similar phenotype with ageing in several ways, and together they have synergistic effects on metabolic and cognitive health, resulting in the progressive decline in functions of various tissues and organ systems. Importantly, obesity is not merely the passive accumulation of fat or storage of excess calories; rather, it is an active and disruptive biological state that accelerates ageing process, often rendering individuals biologically older than their chronological age. The shared hallmarks of ageing and obesity, such as low-grade inflammation (“Inflammaging”), impaired proteostasis and autophagy, mitochondrial dysfunctions, DNA damage, excessive ROS generation, oxidative stress, etc., mediate their bidirectional causality and predispose older adults to adverse health outcome in later years of life. This book brings together comprehensive reviews and critical analyses examining the bidirectional and complex relationship between obesity and ageing. Further, the emphasis is on the roles of key biological modulators that mechanistically link obesity with ageing processes and longevity outcomes. Another central achievement of this book is in presenting expert opinions grounded exclusively in scientific evidence aimed at developing comprehensive and targeted interventional strategies for obesity management in older adults. These strategies are particularly aimed at maintaining, improving, and recovering health in ageing populations, thereby promoting healthy ageing and longevity. This multi-chapter book is organized into three distinct parts. Part I presents an overview of the bidirectional relationship between obesity and ageing, emphasizing the importance of defining and phenotyping obesity within the context of ageing. This section explores how obesity can accelerate the ageing process and examines genomic, epigenomic, and evolutionary perspectives linking obesity with ageing and longevity. In addition, experts discuss the mechanistic role of neural and endocrine systems in driving age-related adiposity, along with its consequences on metabolic and brain health. Part II comprises a collection of chapters that provide comprehensive reviews and critical analyses of the existing scientific evidence, highlighting the roles of various biological modulators in obesity and ageing. The chapters in this section examine the role of low-grade inflammation, gut microbiota, sleep alignment with circadian rhythms, the interplay between brain health, oral health, renal health, and obesity, as well as inter-organ cross-talk in the context of obesity and ageing. Finally, Part III collates expert opinions on evidence-based dietary recommendations for obesity management, highlighting the significance of plant- versus animal-based dietary patterns. It also examines non-pharmacological interventional strategies, including gut microbiota and gerobiotics, caloric restriction mimetics, and physical activity in the management of obesity to promote healthy ageing and longevity. In addition, this section discusses the potential benefits of nutraceuticals, phytochemicals, and conventional drug-based pharmacological interventions for the maintenance, promotion, and restoration of metabolic health during ageing. Expert opinions are further provided on the role of chrono-nutrition and emotional regulation as emerging interventional strategies for sustaining overall health. A central message emerging from this collection of articles is the need to understand how organ- and tissue-specific adiposity accelerates ageing and impacts physical and mental health in later life. The volume further emphasizes the importance of identifying obesity related epigenomic biomarkers for evaluating the impact of adiposity on biological ageing and adopting timely lifestyle strategies that can help maintain, enhance, and even restore metabolic health with advancing age. In addition, the experts highlight several other contributing factors driving the rising prevalence of obesity among ageing populations, such as the societal challenges that lead to psychological stress, social isolation, limited access to preventive healthcare, and exposure to environmental pollution. The book Obesity, Ageing and Longevity is intended for undergraduate and graduate students, researchers, educators, and geriatric clinicians. It serves as a comprehensive source of up-to-date scientific information, critical insights, expert opinions, and emerging perspectives that facilitate exploration and understanding of the bidirectional relationship between obesity and ageing. In addition, the book will be a valuable resource for healthcare institutions and related organizations, supporting evidence-based policy formulation, clinical recommendations, and strategic decision-making for obesity management, a pressing global public health challenge in ageing populations.