Obesity is a complex condition and, although much remains to be elucidated, our understanding of the many facets of overweight and obesity has advanced greatly over the last few decades. Current research is often focussed on the genetic and molecular patho-physiological drivers which derange energy balance and lead to excess body fat, but it is important that clinicians have an appreciation of the history and context of these findings and an awareness of the significant challenges created by the different features of obesity that continue to be revealed. Different patterns of obesity emerging across the world may also have different impacts on the public health burden and may require a different approach to the development of prevention and treatment strategies.
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