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The first edition of the Dermatology and Venerology textbook by Egon Keining in Mainz and his academic student Otto Braun-Falco was published by Lehmann’s Verlag in Munich in 1961, as was the second edition in 1969. Since then, the textbook has been continuously revised and expanded in its successive editions. A number of foreign language translations have been published over the years. The present 4th English edition is largely based on the 7th German edition released in 2018. As in previous editions, expert knowledge of colleagues from Austria, Switzerland, Cambodia, Canada, Japan and the USA was incorporated, partly on new topics. Notably, a new timely chapter on COVID infections has been added. The editors are also represented as authors in their areas of expertise. To our great pleasure, Prof. Lars E. French, Director of the Department of Dermatology and Allergology at the Ludwig Maximilian University (LMU) University Hospital, has joined the editorial team. In addition to the print version, an electronic version, as well as electronic access to individual chapters, is offered to meet the needs of international readers. Our special thanks go to all the colleagues who have contributed their expertise here as authors. In today’s impact factor-driven world, a large group of particularly motivated authors is required for a such a comprehensive book covering the broad spectrum of dermatology. Few countries in Europe or on other continents are traditionally as broadly positioned as dermatology in German-speaking countries. Thus, the presentation here of our specialty, including dermatology, venereology, and allergology, is broad and somewhat distinct from other textbooks in the field.