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Most students in our organic chemistry courses are not chemistry majors. We wrote this book for those students and anyone who wants a broad yet modern introduction to the subject. We stress general principles because it is impossible to memorize all the details of this vast subject. We want students to learn to make connections, recognize patterns and trends, and use a set of organizing principles to make the material more manageable and understandable. Students who will be taking standardized exams, like the MCAT, will benefit from using this text and gaining a deep understanding of the material. We also believe that the skill of critical thinking is emphasized in this text. This skill will help in science courses taken in the future and, more important, in future decision-making. Although we have made substantial changes to the fifth edition that will benefit students using this book, the voice remains the same. It is personal and talks directly to the student not only about the material at hand, but also about the “how and why” of organic chemistry. We believe it is much easier to enjoy, and learn, organic chemistry if a strong focus on “Where are we and why are we here?” and “What is the best way to do this?” is maintained. On occasion, we try to help students through a tough part of the subject by pointing out that it is tough and then suggesting ways to deal with it. When we talk to students, we try to use our experience to help them succeed, and the book tries to do the same thing.