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Being diagnosed with Crohn’s disease or ulcerative colitis (together called inflammatory bowel diseases, or IBDs) is overwhelming, but the past 10 years have brought incredible advances in our understanding of the natural history of these diseases and a parallel set of advances in treatment strategies for these conditions. Although it’s still true that we don’t know the causes of Crohn’s disease and ulcerative colitis (but are getting closer!), it’s no longer true that people diagnosed with these intestinal conditions must plan for a life of uncertainty, worrying about the next flare or complication from an uncontrolled progressive disease. In fact, we now have an extensive and ever-growing number of effective and safe treatments, new noninvasive methods to proactively monitor the intestines for inflammation and disease relapse, and a better appreciation of how to incorporate dietary strategies into a person’s management plan for a preserved and improved quality of life. I believe that we’ve officially entered the “era of disease modification” in IBD. We can now change the course of the diseases with the newly available and scientifically validated management strategies. This means that someone who’s diagnosed with IBD in 2022 should expect to have stable disease control, to avoid many of the historically described complications of these conditions, and to live a full and unrestricted life.