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The Handbook of Engineering Systems Design provides the first authoritative survey of the state of the art of the engineering systems design perspective, written by leading experts. The Handbook will be a resource for engineering systems design scholars and enable industry practitioners, policymakers and researchers in other fields to discover, apply and further develop the thinking, methods and results. And it is time for learning about and applying the engineering systems perspective: The world is facing a series of challenges which require global effort to overhaul existing technical infrastructures in close synchrony with social transformations in our societies and reforms in institutional governance. In engineering systems design, technology is seen within a wider socio-technical systems perspective, approaching our world as made up of global engineering systems such as the energy system, the transport system and the healthcare system, which are moreover connected by multiple technical, social and institutional links all over the world. This Handbook provides you with the means to shape these global engineering systems by designing interventions and thus provides a basis for addressing the global challenges. The Handbook is the result of a joint editorial effort by the Technical University of Denmark (DTU) and the Delft University of Technology (TU Delft), bringing together expert knowledge of the field of engineering systems design within the wider academic and practitioner landscape across the globe. With all scholars who contributed to giving the state of the art in the field, this Handbook unlocks for you the richness and importance of engineering systems design.