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Symptoms of diabetes are recorded as far back as 400 BC; the Indian physician Sushruta describes diabetes in an ancient Hindi document as “madhumeha” or the honeyed-urine disease. Around 150 AD, the Greek physician Aretaeus of Cappadocia wrote: Diabetes is a remarkable disorder, and not one very common to man. It consists of a moist and cold wasting of the flesh and limbs into urine… the secretion passes in the usual way, by the kidneys and the bladder. It is of improbable, also, that something pernicious, derived from other disease which attack the bladder and kidneys may sometimes prove the cause of this affliction. The patients never cease making water, but the discharge is as incessant as a sluice let off. This disease is chronic in character, and is slowly engendered, though the patient does not survive long when it is completely established for the marasmus produced is rapid and death is speedy. For many centuries thereafter, diabetes mellitus was regarded as a disease of the kidney.