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This textbook provides a calculus-based coverage of statistics and introduces students to methods of theoretical statistics and their applications. It assumes no prior knowledge of statistics or probability theory, but does require calculus. Most books at this level are written with elaborate coverage of probability. This requires teaching one semester of probability and then continuing with one or two semesters of statistics. This creates a particular problem for nonstatistics majors from various disciplines who want to obtain a sound background in mathematical statistics and applications. It is our aim to introduce basic concepts of statistics with sound theoretical explanations. Because statistics is basically an interdisciplinary applied subject, we offer many applied examples and relevant exercises from different areas. Knowledge of using computers for data analysis is desirable. We present examples of solving statistical problems using Minitab, SPSS, and SAS.