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The Cambridge Prescriber’s Guide in Psychiatry is intended to complement Stahl’s Essential Psychopharmacology, and the recently published Cambridge Textbook of Neuroscience for Psychiatrists. The former emphasises mechanisms of action and how psychotropic drugs work upon receptors and enzymes in the brain, while the Cambridge Textbook of Neuroscience for Psychiatrists reviews the wider understanding of neuroscience in psychiatry and its application to clinical practice. Thus, the Guide gives practical neuroscience-based information on how to use psychotropic drugs in clinical practice. We have used the tried, tested and popular format of Stahl’s Prescriber’s Guide, adapting it for a British- English readership and prescribers relying on a UK formulary. We have taken the unusual step of involving tomorrow’s prescribers in the production of the Guide: student doctors at the School of Clinical Medicine, University of Cambridge. They reviewed the available pharmacological evidence and existing clinical guidelines according to templates and under the supervision of experienced consultants and pharmacists as Associate Editors; most of these Associate Editors are our clinical colleagues within the Cambridgeshire & Peterborough NHS Foundation Trust (CPFT). This information was then reviewed, cross-checked, and edited further. Through this inter-generational professional partnership, we hope to have excited the students’ interest in psychopharmacology and psychiatry while integrating the art of clinical practice with the science of psychopharmacology as seen through fresh eyes. We cannot include all available information about every drug in a single work, and no attempt is made here to be comprehensive. The Guide comprises punchy information and essential facts to help prescribers in everyday practice. Unfortunately, it also means excluding less critical facts and arcane information that may, nevertheless, be useful to the reader. To include everything would make the book too long and dilute the most important information. In deciding what to include and what to omit, the editorial team has drawn upon common sense and many decades of combined clinical experience. To meet the needs of the clinician and to facilitate future updates of the Guide, the opinions of readers are eagerly solicited. Feedback can be emailed to PrescribersGuide@ cambridge.org. Any and all suggestions and comments are welcomed. As in Stahl’s Prescriber’s Guide, the selected drugs are all presented in the same format in order to facilitate rapid access to information. Specifically, each drug is broken down into five sections, each designated by a standard colour background: Therapeutics, Side Effects, Dosing and Use, Special Populations, The Art of Psychopharmacology, followed by Suggested Reading. Therapeutics covers the brand names in the UK and if the generic form is available; the class of drug; what indications it is prescribed for as in the British National Formulary (BNF) in bold and other common non-BNF indications; how the drug works; how long it takes to work; what to do if it works or if it doesn’t work; the best augmenting combinations for partial response or treatment resistance; and the tests (if any) that are required. Side effects explains how the drug causes side effects; gives a list of notable, lifethreatening or dangerous side effects; gives a specific rating for weight gain or sedation; and gives advice about how to handle side effects, including best augmenting agents for side effects.