For three hundred years after it was first systematically recorded in Europe Syphilis wreaked havoc, rumbling along through generations of the congenitally infected, a lethal and disfiguring disease without cure. Essentially unmanageable the history of the complaint was more a history of its social journey. By the time of the First World War it showed its sensitivity to an arsenical compound Salvarsan which when shipped to the troops locked in the trenches of the front lines was believed to be the last best hope for humanity. As Penicillin made its way to the troops in the Second World War, Syphilis had been controlled but not defeated, transformed from a medieval scourge into a prosaic irritation.
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