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Principles of Pulmonary Medicine was first published in 1986 as a “concise, core reference [that] emphasizes pathophysiology and diagnosis as the basis for optimal management of respiratory disorders. Physiologic, radiologic, and pathologic features of diseases are correlated with clinical findings providing an integrated, comprehensive approach.” Much has changed over eight editions of the book and the more than 35 years that have elapsed since the first edition. Our understanding of many disease processes has improved, our diagnostic tests have become more sophisticated, and our therapeutic armamentarium has been expanded and improved. The single author of the first four editions, Steven E. Weinberger, MD, MACP, FRCP, was joined starting with the fifth edition by two additional authors, Barbara A. Cockrill, MD, and Jess Mandel, MD, MACP, FRCP; their knowledge, experience, and perspectives have greatly enhanced the quality of the book. Since the fifth edition, we added and subsequently expanded supplementary images and self-assessment questions accessible on the internet, recognizing the importance of learners being able to assess their knowledge and their understanding of concepts that can at times be difficult to grasp. Although the primary audience has always been the medical student taking a respiratory pathophysiology course, the book has also been extensively used by residents and practicing physicians and by other healthcare professionals who care for patients with pulmonary disease. A persistent goal throughout all editions of the book has been to present physiologic concepts, pathogenetic and pathophysiologic mechanisms, and radiologic and pathologic correlates of disease in a clear fashion that can be easily understood even by the beginning student of pulmonary medicine. We have also continued to include margin notes throughout the text, which summarize the major points and concepts and allow the reader to quickly review the material. Starting with the second edition, we included three appendices that provide simplified methods for interpreting pulmonary function tests and arterial blood gases, while also presenting sample problems that test the reader’s ability to use respiratory equations, assess pulmonary function abnormalities, and interpret arterial blood gases. Many changes and updates have been incorporated in the eighth edition. Whereas histopathologic and other images were printed in black and white in previous editions, these and additional images are shown in color in the current edition. We have also added more images—particularly plain chest radiographs and computed tomographic scans—to provide additional examples of the appearance of many clinical disorders on imaging studies. Finally, in the era of COVID-19 and new diagnostic and therapeutic options for a number of disorders, we have updated the text to include information about organisms such as SARS-CoV-2 and expanded coverage of new biologic and immunologic treatments available for a variety of diseases. We have been most gratified by the popularity of the textbook, which has been used extensively not only in the United States and Canada but also in other countries throughout the world. Various editions have been translated into Spanish, Portuguese, Italian, Japanese, Chinese, and Polish. Although there may be some differences in diagnostic and therapeutic approaches to pulmonary diseases in different countries, the conceptual underpinnings of physiology, pathophysiology, and disease mechanisms that we are trying to convey in a readable fashion are universal. It has been a pleasure to work with the editorial staff at Elsevier in development of this edition, just as it has been for past editions. We particularly want to express our appreciation to Robin Carter, Content Strategist; Vasowati Shome, Content Development Specialist; Nandhini Thanga Alagu, Project Manager; Bridget Hoette, Book Designer; and the efforts of Elsevier. Finally, we are most grateful to our families for their support and understanding as we had to sacrifice time with them to prepare this new edition of the book.