دانلود کتاب اصول ژنتیک سرطان

Mainstream cancer research has long been focused on the biology of the cancer cell. This approach was logical, as these defective cells harbor the genetic mutations at the root of cancer. But the picture that emerged from cellular studies alone was bound to be incomplete. Cancer, in its many forms, is a systemic disease. Studies exclusively focused on the autonomous phenotypes of the cancer cell failed to fully capture the complex, highly dynamic interactions between neighboring cancer cells and the normal cells that surround them. The most significant of these intercellular interactions involves cells that mediate the immune responses to pathogens. This new edition of Principles of Cancer Genetics delves deeply into the intimate relationship between the immune system and cancer. Iconoclastic scientists, working for decades in relative obscurity, have demonstrated that cancer cells are themselves obscure, at least as far as immune recognition is concerned. A more systemic approach to understanding and treating cancer has recently gone mainstream, as a large and growing body of conclusive evidence supports the role of the immune system as the ultimate barrier to tumorigenesis. Tumors are certainly a manifestation of uncontrolled cellular proliferation, but the disease we broadly refer to as cancer is equally dependent on immune escape.