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In my training in the 1970s I was guided by many clinicians and also by books. Those large neurology tomes were useful, but it was the smaller texts that gave me insight into clinical practice. One by Dr Bryan Matthews, later Professor of Clinical Neurology at Oxford, was Practical Neurology published in 1963, when Matthews was a general neurologist in Derby. His was a book I could enjoy. Some comments are etched in my memory: ‘There are many admirable textbooks of neurology but it is a matter of common observation that they are of more assistance in the passing of written examinations than in the management of practical problems’. Another, quoting Sir Geoffrey Jefferson, remarked ‘ . . . in life the tracts are not marked in red . . .’ And, from Matthews on dizziness: ‘ . . . there can be few physicians so dedicated to their art that they do not experience a slight decline in spirits on learning that their patient complains of giddiness.. . .’ There was thus some logic in taking Neurology: A Queen Square Textbook, Second Edition, the major reference work that I initiated and edited with colleagues, and turning it into this shorter, practical book. I hope this Handbook will serve two purposes. First, it is to be read – each chapter aims to give a brief overview of an area of neurology. Secondly, this book, a synopsis of our subject, provides a pointer to Neurology: A Queen Square Textbook in its forthcoming Third Edition, a completely separate project that has been fully updated and enhanced by Robin Howard, Dimitri M. Kullman, David Werring, and Michael Zandi. Neurology: A Clinical Handbook is based on the second edition of Neurology: A Queen Square Textbook. The editors and authors of Neurology: A Queen Square Textbook have not been involved in the development of this Handbook.