دانلود کتاب درمان ضد میکروبی نوزادان نلسون – ویرایش دوم

Optimizing antibiotic use in neonates is a complex task. To select the ideal treatment for suspected or proven infection, health care professionals must weigh a variety of factors. These include the rapidly changing physiology, volume of distribution, and antibiotic clearance of newborns; the susceptibilities of the offending pathogen(s); whether or not a given antibiotic penetrates the infected body compartment (eg, into cerebrospinal fluid); the toxicity of the antibiotic regimen; and the short- and long-term effects of antibiotic exposure on the neonate’s microbiome. Nelson’s Neonatal Antimicrobial Therapy aims to help health care professionals select the right drug, dose, and duration for neonates. This chapter provides an overview of antibiotic selection and a primer on the types and classes of antibacterials and antifungals commonly used in neonates. New drugs should be compared with others in the same class regarding antimicrobial spectrum, efficacy, toxicity, and cost. If there is no substantial benefit to efficacy or safety for one antimicrobial over another, health care professionals are encouraged to opt for an older, more extensively used, and less expensive drug with the narrowest spectrum of activity.