دانلود کتاب نانوتراپی برای تحویل داروی تومور مغزی

Brain cancer is the leading cause of cancer-related deaths in patients younger than 35 years. Glioblastoma also known as glioblastoma multiforme (GBM) accounts for ~40% of primary brain tumors, taking more than 15,000 lives in the USA every year [1]. GBM tumors are characterized by extensive vascularization, a high mitotic index, cellular pleomorphism, genomic instability, and tissue necrosis. GBM is not curable with surgery alone because tumor cells invade into the surrounding brain, rendering complete resection unfeasible without major brain injury. The current standard of care for patients withGBM consists of surgery for maximal resection or biopsy followed by radiation and chemotherapy. Without treatment, most patients live fewer than 6 months. With the most aggressive combination therapies, the mean survival is still less than 18 months, often with devastating neurological consequences. Importantly, the survival statistics for patients with GBM have improved only incrementally during the last 30 years. The limited progress and few recent advances strongly underscore the importance of developing new innovative therapeutic approaches and testing them in advanced animal models. This Neuromethods book series entitled Nanotherapy for Brain Tumor Drug Delivery provides a guide on nanoformulations and other drug delivery approaches to both academic and industry scientists. The book includes a total of 12 chapters from the leading experts in the field, covering diverse research topics, methods, and protocols, in nanoparticle drug delivery, gene therapy, neurosurgical brain implant, exosomes, MRI-guided focused ultrasound (MRgFUS), and advanced preclinical GBM animal models.