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Treating various pain conditions is one of the oldest activities of medicine. However, it was not until recently that the discipline of chronic pain medicine was introduced in clinical practice. As chronic pain is described as a very personal experience, pain fellowships around the globe experimented with assorted curricula with various degrees of a mix of procedures and medical management. In the United States alone, in the more than 100 fellowship programs, topics taught vary widely as detailed instructions on what is considered essential learning for pain fellows is lacking. As such, the Association of Pain Program Directors (APPD), its executive board in collaboration with American Society of Regional Anesthesia and Pain Medicine (ASRA PM), decided that it is the time to standardize the requirements, at least their theoretical component, that are needed for pain fellows to graduate. From this initiative came this book, Multidisciplinary Pain Medicine Fellowship: Educational Guidelines by Program Directors. Its editor, Magdalena Anitescu, in collaboration with the APPD contributors, designed the curriculum in 11 parts, each with an essential topic that is explored in detail and supported with extensive references for up-to-date information on the subject explored. Part I explores the diagnosis and non-interventional treatment of chronic pain conditions while Part II addresses approaches to various interventions, procedures, and surgeries that can be used in treating chronic pain conditions. Additionally, it describes in detail common challenges and their potential resolution that fellows face upon graduation from a pain fellowship; those include, among others, contract negotiation, enhancing practice through research, and how to start a solo practice. We believe that this book offers a comprehensive view of what the pain fellows will need to know upon graduation, and we strongly advise using this comprehensive review to enhance local curriculum in pain fellowships across the nation and to be used for practitioners and trainees worldwide. In the time where pain medicine is such a dynamic and innovation incubator, we need to ensure that next generations of pain practitioners speak the basic common language of our specialty. This book is intended as a massive reference for pain fellows preparing for the pain boards, for pain Program Directors who need to ensure pain fellows are learning the latest developments in pain management, for junior practitioners in need of quick review of conditions that they have not seen often, as well as for more established practitioners that need to update their practice in a quick review.