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The first volume of the Handbook of Clinical Neurology was published in the 1960s. One of us, JerryW. Swanson, was introduced to the Handbook of Clinical Neurology by his first neurologic mentor, Nicholas A. Vick, while a student at the Feinberg School of Medicine at Northwestern University in the mid-1970s. Prof. Vick pointed out the depth and breadth of the early volumes, describing them as encyclopedic. It is a testament to the value of the Handbook of Clinical Neurology that it has not only survived but thrived into the 21st century. While there have been prior volumes of the series devoted to headache in 1968, 1985, and 2010, these two new volumes are the first devoted exclusively to migraine. It is appropriate to place such a focus on migraine for many reasons. Migraine is the most common headache disorder for which patients seek care. Migraine has been identified as the second-most disabling disorder worldwide and the most disabling among young women. The last 30 years have ushered in major advances in the understanding of the pathophysiology of migraine and new, effective treatments for this disorder have been developed. There has been increased understanding of the comorbidities of migraine and the role they play in the burden on those with migraine. Volume 198, Migraine Biology, Diagnosis, and Comorbidities, reflects the major advances in the understanding of migraine. This book encompasses sections that focus on the human and societal impact of migraine, the biology of migraine, migraine diagnosis, and episodic syndromes that may be associated with migraine. Volume 199, Migraine Management, is divided into sections on migraine management, evidence-based treatment guidelines, outcome measures, treatment of other migraine subtypes and in specific situations (e.g., hemiplegic migraine, vestibular migraine, and status migrainosus), and finally, potential future directions for migraine research and treatment. It is gratifying to see the breadth of progress in migraine management that can improve patients’ lives. It provides ample evidence, as our friend, Professor Ralph Jozefowicz of the University of Rochester in Rochester, NY, has succinctly observed related to therapeutic progress in neurology: “The practice of neurology is no longer diagnose and adios.” Indeed, patients with migraine headaches expect and deserve both an accurate diagnosis and effective treatment. We thank the series editors for the opportunity to contribute these volumes to the Handbook of Clinical Neurology. We also acknowledge the important contributions of the development editors, Michael Parkinson, who died during the preparation of the volumes, and Kristi Anderson, who has so ably succeeded Michael. Authors from around the globe have graciously contributed to these volumes, doing so during the challenging COVID-19 pandemic.We are grateful to them for their efforts. Finally, we want to thank our families without whose support, understanding, and patience, this work would not have come to fruition. Our goal for these volumes is that they serve as a resource for those who devote themselves to the field of headache medicine and care for patients with migraine. The ultimate aim of these volumes is that they will be useful to those who care for migraine sufferers and contribute to the improvement of their lives.