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Oncology is a rapidly evolving field. In the last few years, we have seen a dramatic improvement in the outcomes for patients with cancer with the advent of new modalities for treatment, particularly with immunotherapy. We have seen multiple new therapeutic approvals for several cancers. We are amid a dramatic shift in our treatment paradigms with a significant impact on survival—even for cancer types that seemed incurable, we have seen durable responses and survivals in the metastatic setting. As we develop more effective therapeutics and extend survival in patients with cancer, we are faced with unique challenges with the management of potential toxicities with these treatments. It is imperative that oncology providers and providers who manage patients with cancer are aware of the mechanisms of these complications as well as the appropriate diagnostic and treatment approaches. In this handbook, disease area specialists with expertise in managing cancer treatment-related adverse events have covered many aspects of oncology, from basic pathophysiology of the toxicities to the current state-of-the-art management of these treatment-related toxicities. This succinct handbook provides a quick guide to understand the pathophysiology and the management of cancer treatment-related toxicities, therefore it will serve as a practical guide for any professionals involved in the care of cancer patients.