دانلود کتاب روش ها و پروتکل های ژن درمانی سرطان

This book on protocols for Gene Therapy of Cancer is meanwhile the third edition of this successful series. These three editions cover 20 years in evolution of cancer gene therapy and represent a tribute to the accelerated speed of development and still growing attention to this field. Although the main topics in cancer gene therapy, such as immunogen therapy, suicide gene therapy, gene replacement, vector development and refinement, etc., are still in focus, the major activities have significantly shifted over the years. Currently more efforts are made for improved immunogene therapy, based on TCR and CAR engineering, tumor vaccination using DNA or RNA vaccines, and on immune stimulation at different levels. Engineering and use of oncolytic viruses is experiencing a renaissance, stimulated by accumulating knowledge in mechanisms of oncolysis action and its interplay with the immune system. Vector development (viral and nonviral) and gene delivery are taking increasing parts of research in cancer gene therapy. Far more clinical trials for cancer gene therapy are under way to improve the outcome of cancer patients, to learn more about clinical applicability and the needs of optimized and affordable generation of gene therapeutic products as nucleic acid-based pharmaceuticals.