Interpatient variation is a substantial clinical problem when considering drug therapy. Examples of variation include failure to respond to treatment, increased incidence of adverse effects, and increased susceptibility to drug interactions. The concept of ‘one dose fits all’ is clearly incorrect and is demonstrated by the unacceptable rate of hospital admissions caused by adverse drug reactions (approximately 5% in the UK; 7% in the US). This variation is hardly surprising, given all the factors that ultimately determine an individual’s response to a drug.
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