دانلود کتاب بیوتکنولوژی برای ژن درمانی – RNA، CRISPR، نانوربات ها و کاربردهای پیش بالینی

Gene therapy for many investigators is an amazing technological platform for developing novel therapies against life-threatening diseases that are previously untreatable using traditional pharmaceuticals. It is highly unfortunate that controversies and ethical concerns also have been associated with gene therapy. As an example, the discovery of CRISPR-Cas9 and its application as a genome-editing tool has been transformative. It allows investigators quickly and more efficiently to modify genes which is invaluable for studying cellular functions and for developing therapeutics that addresses the underlying problems associated with diseases instead of treating their symptoms. In 2018, a scientist shocked and horrified the world by applying CRISPR to embryos in vitro and creating the world’s first gene-edited human babies. Germ-line gene editing of humans has had a clear ethical line of caution, transparency, and rigorous oversight before it can be crossed because unforeseen consequences to the human genome could cascade throughout the generations. Since this and other controversies have been documented in scientific journals and disseminated to the public by news outlets, the ethics of gene therapy continues to be debated, and the social trust in gene therapy seems to be further eroded.