دانلود کتاب راهنمای عملی کبد شناسی کودکان – ویرایش چهارم

Nearly two decades have elapsed since the first edition of this book. Major advances have occurred in the diagnosis of pediatric liver diseases, particularly in the field of genetic disorders. With the advances in next generation sequencing techniques, many monogenic pediatric liver disorders are becoming precisely diagnosed, as several of them may have common clinical and biochemical presentations especially in the field of cholestatic disorders of infancy. These advances revealed a need for adding a chapter on “Monogenic Liver Diseases” and to stress in the chapter on “Acute Liver Failure” on the need to reach a molecular diagnosis lest the genetic cause may be a contraindication to liver transplantation. This guide has always been directed to the General Pediatrics residents, as a source of practical knowledge that enables them to manage their pediatric patients with liver disease. This guide does not elaborate on theoretical knowledge but is rather a practical guide for diagnosis and management of pediatric liver diseases, emphasizing the clinical presentation, diagnosis and management of these conditions. This inspired us to write detailed management of: e.g. post-Kasai portoenterostomy fever, acute liver failure (with special stress on acetaminophen overdose), hepatic encephalopathy, gastrointestinal bleeding, ascites, spontaneous bacterial peritonitis, plasma transfusion, immunization strategies in special situations and liver involvement in systemic disorders. We hope that this guide will be of help to adult hepatologists to whom our pediatric liver patients will be transitioned in the future; as they have to be acquainted with these disorders that present in early life, but thanks to proper management, these infants and children are now surviving to adult life.