دانلود کتاب اصول و عمل انکولوژی پرتودرمانی پرز، بردی، هالپرین و وازرز

It was probably 2002 when I flew from the Raleigh-Durham airport in North Carolina to the Philadelphia airport. I took a taxi cab (remember those?) to the neighborhood of Independence Hall. It was where the Declaration of Independence was crafted and adopted and the Liberty Bell then resided. I walked south of the national historic landmark into a conference room at the Independence Square home offices of the venerable medical publishing house, J.B. Lippincott. I was being brought on-board to join Carlos Perez and Luther Brady as one of the senior editors of Principles and Practice of Radiation Oncology. Our task was to create the fourth edition. I was seated at a table with Drs Perez and Brady. We were joined by Stuart Freeman, managing editor and representing J.B. Lippincott. As “the new kid on the block” I thought it best to sit quietly and “learn the ropes.” “Do you want to know how I came to create this book in 1987?,” Luther Brady asked me earnestly. By his expression, it seemed clear that he had a story to tell and intended to tell it. “Yes, sir, certainly,” I replied. Carlos Perez cut him off. “Oh no, Luther,” he said. “Edward does NOT want to hear THAT story.” Luther Brady sat back in his chair, looking somewhat deflated. I learned several key lessons: (1) There was only one person I would ever meet who had the authority to tell Luther Brady “no.” (2) That person was the courtly and dignified Carlos Perez. (3) If Luther Brady wanted to tell a story, there was no one, including Dr Perez, who was, in the long run, going to stop him. The meeting to prepare the fourth edition continued for about another hour and it was time for a break. Mr Freeman and Dr Perez left the room. A nanosecond after they left, Luther Brady turned to me. “Let me tell you the story of how I came to create this book,” he said. “Yes, sir, certainly,” I once again replied. “Years ago,” he began, “I sat down with Phil Rubin [the Chair of Radiation Oncology at the University of Rochester] to discuss the need for a definitive textbook to succeed Gilbert Fletcher’s Textbook of Radiotherapy. I had asked Fletcher if he planned on a new edition and he told me the current edition of his book had no need for improvement. We also discussed the need for a definitive dedicated radiation oncology scholarly journal. We agreed that both needed to be created. What we couldn’t agree upon was who would take charge of which project.” I had the feeling that Dr Brady had wanted to be the founding editor-inchief of the radiation oncology journal. I knew that, in fact, he had been the founding editor-in-chief of the American Journal of Clinical Oncology, but I said nothing and urged him to continue his tale. “Well,” he resumed, “we flipped a coin and Phil got the journal and I got the book. That’s why Phil was the founding editor of the International Journal of Radiation Oncology Biology Physics, generally called the red journal, and I created this book!” As a part-time historian, I would like to have independent verification of this coin flip story from an objective third party, but I don’t have it. Whether it is the founding story of this textbook or the founding myth, I am unable to say. Whichever it is, the book you hold in your hands, which emerged from that coin flip, may be rightly referred to as “The Bible of Radiation Oncology,” “The New York Times of Radiation Oncology,” or, as I often hear, “The Book.” I have come to be one of the stewards of the edifice created by Drs Perez and Brady. I have taken that responsibility seriously. Drs Perez and Brady asked Rupert Schmidt-Ullrich to join the team of senior editors for the fourth edition. Unfortunately, Rupert passed away before we could prepare the fifth edition. David Wazer joined as an associate editor for the fifth edition in 2008 and moved up to join me as a senior editor for the sixth and subsequent editions. Drs Perez and Brady continued to actively work on the book until Dr Brady’s death as the seventh edition was being prepared for publication in 2018 and Dr Perez’s death as we were collecting chapters for the eight edition. Since it takes about 2 years to prepare each edition, Dr Perez devoted 39 years to this book; Dr Brady devoted 33 years; I have devoted 22 years to four editions so far; and David Wazer has devoted 18 years to three editions so far. Those are big numbers. From the first edition of the Principles and Practice of Radiation Oncology in 1987 to this eighth edition being published in 2025, we have clocked 38 years, approximately 13,300 pages of printed text, many tens of thousands of pages of typed and computer printed text, and an immeasurable number of meetings, phone calls, letters, e-mails, faxes, and text messages to produce these eight editions. Many things have changed and others have stayed the same. What has stayed the same? For 38 years, radiation therapy has remained a major component of the curative and palliative therapy of cancer and plays a major role in the management of many benign diseases. Patients with cancer are generally best managed by a combined modality approach that requires the participation of a well-informed, well-trained, and wellequipped radiation oncologist and medical physicist collaborating with a radiation oncology team. The radiation oncologist must be capable of taking a detailed medical history; performing a thorough and accurate physical examination of the patient; assessing and integrating the information from diagnostic imaging, from gross and microscopic pathology—incorporating a growing list of chemical and molecular markers that guide therapy and predict outcome—and from clinical chemistry; and formulating and implementing a treatment plan that is cognizant of the wishes of the patient and realistic in its goals. For this book, in particular, what has also stayed the same since 1987 is the vision and participation of the editorial team. Having such stability in the editorial team is exceptional in the history of textbook publishing. As we note in our acknowledgments, we remember and mourn those who contributed to previous editions of this book but are no longer with us: Ruth Aultman, Jonathan Pine, Rupert Schmidt-Ullrich, Carlos Perez, and Luther Brady. What has changed? There has been an explosion of knowledge concerning the molecular biology of cancer and tumor physiology. Concepts that were unknown in the 1980s are now considered fundamental building blocks of knowledge concerning cancer. As it concerns the technology of this specialty, when the first edition of this book was published, some radiation oncology residents were training, in part, on orthovoltage units; cobalt-60 machines remained in widespread use; simulation using diagnostic radiographs still vied with clinical setups of treatment fields using surface anatomy; and many radiation oncologists carried slide rules, protractors, right angle drafting triangles, and rulers to calculate and map radiation dose distributions. Now, elaborate linear accelerators with multileaf collimators, particle machines, intensitymodulated and/or image-guided radiation therapy, complex brachytherapy devices, dose painting, image fusion, metabolic imaging, and increasingly powerful computers that support the preceding list of technologies have become the norm in the developed world. (And, unfortunately, the paucity of even the most minimal radiation therapy services remains the norm in many parts of the economically less-developed world, and economic and racial disparities persist in cancer care and outcomes in the economically developed world.) In some diseases, the diagnostic and staging workup has changed profoundly in the past quarter of a century—for example, the role of staging laparotomy in Hodgkin disease. In other diseases, the role of radiotherapy in treatment has shifted dramatically, as demonstrated by the decline in the role or frequency of use of radiation therapy in the management of retinoblastoma, Burkitt lymphoma, and Wilms tumor, following balloon angioplasty and stenting for coronary artery disease, and AIDS-associated malignancies. There have been significant changes in the patterns of use of radiation therapy for breast and prostate cancer, brain metastases, and non–central nervous system oligometastases. The editors have striven to be cognizant of change by constantly adding and pruning chapters to document the current state of knowledge of cancer biology, medical radiation physics, dosimetry, cancer epidemiology, clinical radiation oncology, and radiation oncology economics, education, ethics, and policy. Particular attention has been devoted to an attractive and usable design of the printed version of this book and the new electronic versions. We have taken care to have this book evolve with the times. We have simultaneously striven to be true to the core mission of being “the book of record” for clinical care, providing the data that justify treatment recommendations as well as comprehensive illustrations and references in radiation oncology. We take this responsibility very seriously. We have been gratified by the public reception of this book. Sales of the fifth edition rose dramatically compared to the fourth edition—an atypical pattern in the medical book business. Sales of the sixth and seventh editions remain high. It is, we like to believe, evidence that the pact wordlessly exchanged between the editors, the chapter authors, and our readers is being honored by all parties. The editors sincerely hope that this eighth edition of Principles and Practice of Radiation Oncology will continue to advance the understanding of the causes, prevention, and treatment of human cancer. We pray that this new edition will contribute to the cure of some malignancies, the amelioration of suffering for many patients and their families, the relief of pain, and the ultimate triumph of human knowledge over cancer. I began this preface with stories that included the fact that Drs Perez and Brady worked on this book until they died. Dr Wazer and I hope to have many fruitful years to continue working on the ninth edition and its successors. We have both decided, however, that prudent responsibility for this international treasure of a book includes both having a long-term succession plan for its leadership and increasing the diversity of the editorial team. We have, therefore, invited Drs Baumann, Blitzblau, and Esiashvili to join the team as associate editors for the eighth edition and begin “learning the ropes,” as I did back in that Philadelphia conference room over 20 years ago. Immediately following this preface, the reader will find a page of acknowledgments from all five senior and associate editors. I will, however, take the prerogative as the author of this preface to particularly acknowledge David Wazer. David has negotiated the personalities and politics of editorship and publishing with a calm hand, a steady gaze, and a mission-driven focus. He has done all of this while being a busy clinician, journal editor, and academic leader. He has also done all of this while dealing with the curve balls that life often throws you. Both David and I can testify that “Getting old isn’t for sissies.” I have been blessed to have him as a partner in creating this book for the last 18 years.