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Like many good ideas in clinical medicine, Trauma Induced Coagulopathy was the product of a multidisciplinary research meeting. As the process unfolded, multiple classic papers were identified that addressed different concepts of coagulation changes following injury. It soon became apparent that consolidation of all of these concepts was too large for practical distribution or synthesis into a review article. We agreed the most useful reference would be a text of chapters written by those conducting research in various fields related to coagulation resulting in the first edition of Trauma Induced Coagulopathy in 2016. With the growing interest in understanding and managing coagulation in trauma, an updated second edition was due. During this interval, the Trans-Agency Consortium on Trauma Induced Coagulopathy (TACTIC), supported by the National Institutes of Health and coordinated with clinical trials funded by the Department of Defense, made significant efforts to enhance multidisciplinary research in trauma resulting in countless new discoveries. International collaboration and consensus resulted in a definition of TIC proposed by a working group of the International Society of Thrombosis and Hemostasis (ISTH). Several large clinical trials were also completed during this time, in addition to new clinical devices for measuring coagulation. The second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. At the time of publication, the world is focused on the vexing problem of COVID-19, and we have rapidly come to realize that a profound hypercoagulable state markedly contributes to morbidity and mortality. Knowledge gained from our collaborations and summarized in this text is now being deployed against the COVID-19 associated coagulopathy. At the same time, uncontrolled hemorrhage remains the leading cause of preventable death following trauma throughout the world, and the driving mechanisms remain to be established.