دانلود کتاب سنتز و خصوصیات گلیکوزیدها

The third edition responds to the need for providing students and professionals involved in the glycoside chemistry discipline with updated information regarding emerging and consolidated methods for preparingO-, N- and C- glycosides in order to ensure a collection of synthetic tools useful for their research. This newedition incorporates information regarding green chemistry for using biomass to produce furfural derivatives, iminosugars, thiosaccharides, more mechanistic evidence to understand and to drive glycosyl reactivity and stereoselectivity, the use of chiral auxiliaries, and additional protecting and deprotecting reaction conditions. In O-glycoside chapter, you will find more evidence about stereocontrolled glycosylations, promoter systems, latent-active strategies, the development of glycosyl donors such as alkynyl, fluoride, phosphate donors and their potential. Also, a description on photoactivated, electrochemical glycosylation reactions, as well as automated glycation progress for the synthesis of complex oligosaccharides is outlined. The chapters regarding N- and C- glycosides including glycoside mimetics and glycoconjugates are devoted to review methods for preparing either conserved or modified nucleotides currently used as antivirals, antitumoural or glycemic control drugs, using silyl, enzymatic, electrophilic and nucleophilic glycosyl donors or following oligonucleotide approach, the later for preparing third generation antisense drugs used for treating numerous degenerative diseases. The chapter referring glycoconjugates contains recent approaches for preparing glycopeptide and glycoprotein analogues by using native chemical ligation strategies, and also novel glycosphin golipid and gangliosides are described used as vaccine adjuvants. Finally, recent information was incorporated in the study of glycosidases focusing on structural features and transition state details introducing photoswitchable substrates in order to provide better understanding at their catalytic site level and for improved enzymatic detection.