دانلود کتاب سارکوئیدوز – مونوگراف – ERS

Sarcoidosis is a systemic, multi-pathway disease and a clinical chameleon. Recent reports indicate that the prevalence of sarcoidosis is rising and the mortality in patients suffering from chronic sarcoidosis is increasing [1]. The high variability of manifestations, from asymptomatic to life-threatening, depends on organ involvement and disease activity, which still lacks a clear definition. About half of patients experience a chronic course. The consequences on quality of life and wellbeing can be devastating, especially if patients are not promptly referred to sarcoidosis specialists. To date, there are few approved treatments for sarcoidosis, mostly based on expert opinion, and the majority of investigational drugs have failed in clinical development. Although enormous advances have been made in the understanding of the disease pathogenesis and in the development of new diagnostic tools and management strategies, the burden of sarcoidosis, both socially and economically, is still considerable and the unmet needs persist.