دانلود کتاب فارماکولوژی پزشکی و درمانی

The sixth edition of Medical Pharmacology and Therapeutics has been revised and updated to build upon the strengths and popular approach of previous editions. Its aim remains to provide a single volume for healthcare professionals and students requiring a sound knowledge of the basic principles of clinical pharmacology combined with the practice of drug prescribing for the management of disease. Medical Pharmacology and Therapeutics relates key information on basic pharmacology to other relevant biomedical sciences in order to underpin the clinical contexts, and each disease-based chapter is then structured to reflect the ways that relevant drugs are used in clinical practice. The chapters covering generic concepts in pharmacology and therapeutics include sections on drug action at a cellular level, pharmacokinetics, pharmacogenetics, drug development, drug toxicity and the principles of prescribing. The sections on clinical management in each disease area have been thoroughly revised and updated in line with best practice and the relevant national guidelines, including on COVID-19. Each chapter in this sixth edition retains the following key features: • An up-to-date and succinct explanation of the major pathogenic mechanisms of disease and consequent clinical symptoms and signs, helping the reader to put into context the actions of drugs and the consequences of their therapeutic use. • A comprehensive review of major drug classes relevant to the disease in question. Basic pharmacology is described with clear identification of the molecular targets, clinical characteristics, important pharmacokinetic properties and unwanted effects associated with individual drug classes. Example drugs are covered in depth to illustrate the common pharmacological characteristics of their class and to introduce the reader to those drugs currently in the most widespread clinical use. • A structured approach to the principles of disease management, outlining the core principles of drug choice and planning a therapeutic regimen for many common diseases. • Drug compendia at the close of each chapter enable any drug encountered by the reader in day-to-day work or study to be placed within its drug class and its key features related to the example drugs covered in the chapter. • An expanded section of self-assessment questions for learning and revision of the concepts and content in each chapter, including one-best-answer (OBA), extended-matching-item (EMI), true-false and case scenario-based questions. It is our intention that the sixth edition of this book will encourage readers to develop a deeper understanding of the principles of drug usage that will help them to become safe and effective prescribers, to enable them to evaluate the findings of basic and clinical research, to encourage them to teach and train others in their profession, and to develop the skills of lifelong learning that will enable them to tackle changing healthcare needs and emerging threats.