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The concept for this book was conceived in Howard Maibach’s home office during one of Rebecca Law’s numerous visits. Howard has an enormous home office/library with hundreds of his treasured textbooks and publications. He has already published a systemic drug treatment in dermatology handbook with Sarah Wakelin (currently in its third edition), so clearly a topical drug treatment in dermatology handbook would make a suitable companion textbook. Thus began the recruitment of authors with expertise in specific dermatologic conditions, and authors with expertise in one specific dermatologic category of drugs, or even in one specific drug treatment. With the intent of also providing a learning experience for students and a teaching experience for their mentors, some of our authors have involved their students, residents, and/or fellows in preparation of their chapters. The handbook is in two sections. The first section includes foundational chapters discussing general principles such as factors affecting percutaneous absorption, extemporaneous compounding, pharmacogenomics, factors affecting topical therapy in pediatrics and geriatrics, and systemic considerations when topical drug treatments are used. The second section includes chapters of drug monographs grouped either by disease state (e.g., acne, atopic dermatitis) or drug classification (e.g., antibiotics, corticosteroids) or stand alone (e.g., sirolimus). There is cross-referencing between chapters. The chapters have been reviewed and edited by the editors and by Springer. FDA drug monographs and LexiComp/LexiDrug drug monographs are consistent reference sources for each drug monograph chapter, in addition to specific additional references and readings for each drug treatment. The editors’ hope is to provide a handbook that will be useful to clinicians and educators. We welcome corrections or comments regarding this book.