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The text, Applied Therapeutics: The Clinical Use of Drugs,1 provides a unique blend of factual information and practical application for both the beginning student and the mature practitioner. In the day-to-day management of patients, the clinician often needs quick access to “clinical pearls” to formulate rapid therapeutic decisions. It is for this purpose that the first edition of The Handbook of Applied Therapeutics was published. Now, several editions and many years later, this newest edition has been prepared to reflect the substantial increase in drug knowledge since the 2006 publication of the 8th edition. In these times of national attention on medical errors, escalating costs, and shortages of nurses and pharmacists, we hope that the ready accessibility of clinically important drug information will make The Handbook of Applied Therapeutics a valuable tool for assisting in the safe and efficient use of drugs. The editor has abstracted hundreds of valuable tables and other information from the 10th edition of Applied Therapeutics: The Clinical Use of Drugs. To achieve portability of size, only the most essential data has been included. Therefore, the user is strongly encouraged to refer to the primary text for more detail and for literature documentation.