دانلود کتاب فشار خون غدد درون ریز از علوم پایه تا عمل بالینی

Endocrine causes of hypertension are among the most frequent causes of secondary hypertension, and with the recognition of the increased prevalence of primary aldosteronism, could represent a sizable percentage, perhaps up to 20% of the aetiologies of hypertension. Accurate diagnosis of these conditions is critical because of the complications associated with the persistence of disease in cases in which diagnosis is not made, and because many of these conditions may be cured, in contrast to primary hypertension, which can be controlled but not cured in present times. There are guidelines for diagnosis and treatment of endocrine hypertension from many organizations, such as those of the Endocrine Society of the USA, the 2017 AHA/ACC Guideline, and the latest European Guidelines, both for the management of hypertension in general but including recommendations for endocrine hypertension, and many other sources of recommendations that include how to diagnose and manage endocrine hypertension. However, there is a need for a treatise on endocrine hypertension that addresses in-depth the etiology, pathophysiology and the molecular underpinnings, the differential diagnosis, and the management of endocrine hypertension, including the more practical aspects of treatment and follow-up. Endocrine Hypertension, from Basic Science to Clinical Practice, edited by Joseph M. Pappachan and Cornelius James Fernandez does precisely that. With X chapters written by authorities in the field, Endocrine Hypertension provides an indepth description of all aspects of hypertension with endocrine connotations. From adrenal hyperplasia to acromegaly, and from paragangliomas and pheochromocytoma to Cushing’s, through hyperaldosteronism in its different types to the role of the renin-angiotensin system and the many forms of monogenic hypertension, no aspect of endocrine hypertension is left unexamined. The genetics, molecular and cellular aspects, etiopathogenesis, pathophysiology, clinical description, screening, and diagnosis, and finally management and follow-up including practical tips, all are addressed in clear and readable prose that makes it not only attractive and entertaining but also hugely easy to incorporate into everyday practice. Chapters on catecholamines and the renin-angiotensin system are followed by ones on pheochromocytoma, paragangliomas and different forms of adrenal hypertension, including recent findings on aldosterone-producing cell clusters and somatic mutations in genes encoding for ion channels and ATPases found in aldosteronomas and aldosteroneproducing cell clusters, and all the genetic, cellular, and molecular heterogeneity in adrenals with an aldosteroneproducing adenoma, including the familial forms of primary aldosteronism. Rarer forms of endocrine hypertension such as acromegaly and Cushing’s syndrome, as well as the monogenic forms of hypertension, require high clinical suspicion but it is important that they be diagnosed. The same applies to the notion of the high frequency of primary aldosteronism, which requires testing in most cases of hypertension because it often has more subtle manifestations than the classical Conn’s syndrome, and its diagnosis and treatment can be extremely gratifying and beneficial to patients, with prevention of target organ damage and complications. Anyone interested in hypertension, from genetics to pathophysiology and molecular and cellular manifestations to diagnosis and treatment should be interested in endocrine hypertension and should read this volume if they want to have adequate knowledge of these conditions and be able to practice evidence-based diagnosis and management of hypertensive patients, many of whom will have some form of endocrine hypertension, very often primary aldosteronism, but occasionally some of the more rare forms of endocrine hypertension.