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Medical and scientific investigations are progressing at an astounding pace. It is difficult for any provider, at whatever level, to keep up with the enormous volume of primary research, case reports, review articles, and clinical practice guidelines that are published daily in printed and online forms. The authors of the chapters in this book have carefully reviewed and summarized each specific assigned area and have added their own opinions, based on their extensive clinical experience, to give readers the best possible coverage of these topics in a well-organized and concise form. I thank each author, from mentored fellows to seasoned faculty and practitioners, for their selfless and painstaking efforts to educate our readers with their own unique blends of knowledge, experience, and humanism. The question-and-answer format, intended to mimic the interchanges between mentors and trainees on rounds, has been preserved and carried on from the 1st Edition (1994) to the current 7th Edition (2019) of Endocrine Secrets. But the original goal of 20 questions followed by short and to-the-point answers has been eclipsed by the ever-expanding volume of research discoveries and evidence-based clinical practice guidelines for the multiple conditions and issues in our field. As a result the chapters are necessarily longer now, with more questions and answers than before. I have also added numerous chapters to cover areas that were not covered in previous editions. One chapter is devoted to case-based practical exercises in carbohydrate counting and insulin dose calculations; another tackles the rapidly expanding field of diabetes technology; and yet another details the causes of spontaneous hypoglycemia, including the cause and management of postbariatric surgery hypoglycemia. There are interesting new chapters on pituitary stalk lesions, adrenal incidentalomas, and polycystic ovary syndrome. There is a specific chapter that covers the emerging field of endocrinopathies resulting from the use of immune checkpoint inhibitors. There are now four separate chapters on endocrine surgery. The new chapter on the care and management of transgender patients is one of the highlights of this edition. Finally, I have included a unique and fascinating chapter detailing the state of Endocrinology in Africa, authored by my valued colleagues from Ethiopia, Dr. Helen Y. Bitew and Dr. Abdurezak A. Abdela. I hope the readers of this book will find it readable, enjoyable, educational, and sufficiently comprehensive to enable them to practice Endocrinology at the highest possible level for the benefit of all the patients who entrust their care to them. Never stop learning. And I hope that all your patients reap the benefits of your expanding knowledge, devotion to lifelong learning, and continuing compassion for them.