دانلود کتاب پروتکل های شیمی درمانی و توالی انفوزیون

There are several types of cancer treatment modalities, such as surgery, radiother­apy, chemotherapy, immunotherapy, and targeted therapy, in which the choice of the best therapeutic option will depend on several factors such as type of tumor, stage of cancer, age, and clinical conditions of the patients. Due to the complexity of can­cer, the association of therapeutic modalities has been shown to be effective, such as the application of chemotherapy and/or radiotherapy after surgical procedures or the association of chemotherapy that enhance the effects of radiotherapy.

The combination of anticancer drugs is also widely used, as they combine drugs that have different mechanisms of action, thereby enhancing the anticancer effect of the drugs. Although effective, the definition of chemotherapy protocols must be well planned to ensure maximum treatment efficacy and minimal toxic effects.

To define the best combination between chemotherapeutics, some parameters must be taken into account. Attention should be paid to the mechanisms of action and pharmacokinetic profile of each drug, diluent solutions and drug stability when infused concomitantly, as well as the drug’s toxicity profiles, and the risks of derma­tological toxicity due to vesicant, irritant, or not irritating characteristics. These characteristics are important as they provide safety and efficacy to the treatment.

Some studies highlight the importance of evaluating the order of infusion of the chemotherapy protocol due to possible pharmacodynamic and pharmacokinetic interactions, in which, depending on the infusion schedule, drugs may present antagonistic interactions with reduced therapeutic activity and increased toxicity, as well as depending on the order, they can present synergistic reactions with potentia­tion of therapeutic effects.