دانلود کتاب آلاینده های شیمیایی محیطی و تأثیر آنها بر سلامت

There is a growing interest of the public on the impacts of the environment on health. However, scientists have not a ready solution. Although fatal bacterial infections have been eradicated with the use of new generation antibiotics, other diseases increase rapidly and the demand for new treatments, such as monoclonal antibodies, is mandatory. Since the decoding of the genes of the human genome, questions regarding multifactorial diseases have not been answered. However, there is not yet a convincing theory to explain the etiopathogenesis of these diseases, not even the effectiveness and safety of new drugs. The increase in the prevalence of diseases, such as allergy, autoimmune diseases, neurodevelopmental and neurogenerative diseases such as Alzheimer disease, Diabetes mellitus type I, and cancer, grows and possesses a serious burden to the health system. Since our genes have not changed in the last 50 years, other factors are implicated to the emergence of these “epidemics.”
My clinical work as a pediatrician in Children’s Hospital “Agia Sofia” in the last 20 years, which used to be the main hospital for children in Athens, contributed to my decision to analyze the literature. I realized that the emergency visits for asthma attacks increased. In addition, diseases like first diagnosed diabetes mellitus type I, inflammatory bowel disease, and rheumatoid arthritis soared. These chronic diseases apart from the burden in costs for the health system count for a serious deterioration in the life of patients and their families with life-long consequences.
The above observations were points of skepticism. Was this soaring of allergic and autoimmune diseases phenomenal or pragmatic? Going through the literature, research has proved that the increase is pragmatic. In-depth studying showed me the complexity of the issue and it gave me the opportunity to scrutinize new knowledge regarding the etiopathogenesis of multifactorial diseases and the role of environment by the epigenetic regulation of the genes, which is suggested to be associated with the growing impact of the environment on our genes.