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Antibiotics—the word sends terror coursing through the veins of students and makes many healthcare professionals uncomfortable. The category of antibiotics contains many different classes of drugs that differ in spectrum of activity, adverse effect profiles, pharmacokinetics and pharmacodynamics, and clinical utility. These classes can seem bewildering and beyond comprehension. We believe that taking a logical, stepwise approach to learning the pharmacotherapy of infectious diseases can help burn away the mental fog preventing optimal use and understanding of these drugs. Learning the characteristics of antibiotics greatly simplifies learning infectious disease pharmacotherapy. Students and clinicians who attempt to learn the antibiotics of choice for different types of infections before knowing the characteristics of those drugs never truly understand the context of what they are attempting to learn, and those memorized facts usually don’t stay in memory for long. Once the characteristics of the antibiotics are known, making a logical choice to treat an infection is much easier. This approach takes some time up front, but it will be well worth the effort when one realizes that the pharmacotherapy of all infections is fundamentally similar and logical. It also pays off when you encounter a patient who didn’t read the guidelines for the infection they have and requires an antibiotic regimen outside the norm.